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Vegfatm2Gne
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm2Gne
Name: vascular endothelial growth factor A; targeted mutation 2, Genentech
MGI ID: MGI:1931048
Synonyms: Vegf-A/loxP, VEGF+f, VEGFFlox, VEGFlox, VEGFloxP, VEGFloxP(-)
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52793
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsInsertion of a loxP-flanked neomycin cassette and a loxP site flanking exon 3. This mutation had no effect on the secretion of the protein. (J:52793)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 29 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  21 strains or lines available
References
Original:  J:52793 Gerber HP, et al., VEGF is required for growth and survival in neonatal mice. Development. 1999 Mar;126(6):1149-59
All:  116 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory