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Targeted Allele Detail
Symbol: Vegfatm1Pec
Name: vascular endothelial growth factor A; targeted mutation 1, Peter Carmeliet
MGI ID: MGI:1931047
Synonyms: VEGF120
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:56003
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of exons 6 and 7 with a lox-P flanked neomycin cassette. The neomycin cassette was removed prior to blastocyst injection by Cre-mediated recombination in ES cells, resulting in the final allele. A highly soluble isoform of the encoded protein is expressed from this allele. (J:56003)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 68 assay results
In Structures Affected by this Mutation: 52 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  22 strains or lines available
Original:  J:56003 Carmeliet P, et al., Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [see comments]. Nat Med. 1999 May;5(5):495-502
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory