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Rb1tm2Brn
Targeted Allele Detail
Nomenclature
Symbol: Rb1tm2Brn
Name: retinoblastoma 1; targeted mutation 2, Anton Berns
MGI ID: MGI:1931018
Synonyms: flox19-RB1, pRbL2, pRblox, Rbf, RbF19, Rblox, RbLoxP
Gene: Rb1  Location: Chr14:73183673-73325822 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61961
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  32 strains or lines available
Notes
Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.

References
Original:  J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
All:  123 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory