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Targeted Allele Detail
Symbol: Rb1tm2Brn
Name: retinoblastoma 1; targeted mutation 2, Anton Berns
MGI ID: MGI:1931018
Synonyms: flox19-RB1, pRbL2, pRblox, Rbf, RbF19, Rblox, RbLoxP
Gene: Rb1  Location: Chr14:73183673-73325822 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:61961
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites flanking exon 19 were introduced to the gene by homologous recombination. The targeted allele was verified by Southern blot analysis. (J:61961)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  34 strains or lines available
Animals homozygous for the conditional floxed exon 19 allele did not show any tumor predisposition phenotype, and were of normal fertility.

Phenotypic Similarity to Human Syndrome: Glucagonoma J:216559 in double homozygous Rb1 and Trp53 conditional mutants.

Original:  J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
All:  135 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory