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Targeted Allele Detail
Symbol: Trp53tm1Brn
Name: transformation related protein 53; targeted mutation 1, Anton Berns
MGI ID: MGI:1931011
Synonyms: p53Co, p53F, p53F2-10, p53F2-10F, p53fl, p53Fl, p53Fl, p53flox, p53L, p53lox, p53LoxP, Tp53flox, Tp53flx, Trp53f, Trp53F2-10, Trp53F2-F10, Trp53Fl, Trp53loxP
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
High-grade prostate intraepithelial neoplasia in Brca2tm1Brn/Brca2tm1Brn Tg(Pbsn-cre)4Prb/0 Trp53tm1Brn/Trp53tm1Brn and prostate hyperplasia and intraepithelial neoplasia in Brca2tm1Brn/Brca2tm1Brn Trp53tm1Brn/Trp53+ Tg(Pbsn-cre)4Prb/0 mice

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:61961
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Insertion of loxP sites flanking exons 2 through 10. No effect on the normal function of the gene. (J:61961)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 17 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  207 strains or lines available
Original:  J:61961 Marino S, et al., Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000 Apr 15;14(8):994-1004
All:  943 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory