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Targeted Allele Detail
Symbol: Stat1tm1Dlv
Name: signal transducer and activator of transcription 1; targeted mutation 1, David E Levy
MGI ID: MGI:1930947
Synonyms: STAT-, Stat1-, STAT1-, Stat1 KO
Gene: Stat1  Location: Chr1:52119440-52161865 bp, + strand  Genetic Position: Chr1, 26.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:31325
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. (J:31325)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  41 strains or lines available
Original:  J:31325 Durbin JE, et al., Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996 Feb 9;84(3):443-50
All:  141 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory