En1^tm3(En2)Alj
Targeted Allele Detail

Summary

• Symbol: En1^tm3(En2)Alj
• Name: engrailed 1; targeted mutation 3, Alexandra L Joyner
• MGI ID: MGI:1930621
• Synonyms: En1^2ki, En1^2kin, En1^en2ki
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm3(En2)Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:27767
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: En2 sequences and a floxed PGK-neo cassette were inserted downstream of the En1 promoter. The sequences corresponding to the first 111 amino acids of the reading frame are also deleted. (J:27767)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 32 strains or lines available

References

• Original: J:27767 Hanks M, et al., Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science. 1995 Aug 4;269(5224):679-82
• All: 5 reference(s)