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Tg(Trp53R172H)8512Jmr
Transgene Detail
Nomenclature
Symbol: Tg(Trp53R172H)8512Jmr
Name: transgene insertion 8512, Jeffrey Rosen
MGI ID: MGI:1929642
Synonyms: 172R-H, p53-172H, p53(R172H), Wap-p53R172H
Transgene: Tg(Trp53R172H)8512Jmr  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Trp53R172H)8512Jmr expresses 1 gene
 
Mutation detailsThis transgene contains the rat whey acidic protein promoter and an allele of the mouse Trp53 mini-gene that carries a point mutation in codon 172 (CGC->CAC; Arg172His). (J:46426)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
On an FVB/N background transgenic mice express TRP53 with both dominant-negative and a gain-of function properties.

References
Original:  J:46426 Li B, et al., A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998 Feb 26;16(8):997-1007
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory