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Nrg1tm1Zhou
Targeted Allele Detail
Nomenclature
Symbol: Nrg1tm1Zhou
Name: neuregulin 1; targeted mutation 1, Mingdong Zhou
MGI ID: MGI:1928830
Synonyms: CT-, deltaCT
Gene: Nrg1  Location: Chr8:31814551-32884029 bp, - strand  Genetic Position: Chr8, 18.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50592
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsSpecific disruption of the intracellular domain of the Nrg1 gene. A stop codon and a poly(A) sequence was introduced immediately 3' to the coding region for the first three amino acids of the intracellular domain, followed by a neomycin cassette. (J:50592)
Inheritance:    Recessive
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  17 strains or lines available
References
Original:  J:50592 Liu X, et al., Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13024-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory