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Targeted Allele Detail
Symbol: Erbb2tm1Gne
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Genentech
MGI ID: MGI:1928827
Synonyms: ErbB2-
Gene: Erbb2  Location: Chr11:98412484-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:45302
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of an exon encoding amino acids 256-304 with a neomycin cassette. This mutation disrupts the first extracellular cysteine-rich domain; this region had been demonstated to be the putative ligand interacting site. (J:45302)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  5 strains or lines available
Original:  J:45302 Erickson SL, et al., ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997 Dec;124(24):4999-5011
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory