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Crebbptm1Sis
Targeted Allele Detail
Nomenclature
Symbol: Crebbptm1Sis
Name: CREB binding protein; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:1928768
Synonyms: Cbp-, Crebbptm1Rik
Gene: Crebbp  Location: Chr16:4081328-4213997 bp, - strand  Genetic Position: Chr16, 2.4 cM
Skeletal formation defects in Crebbptm1Sis/Crebbp+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42932
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The exon encoding amino acids 29-265 was replaced by a neomycin cassette. (J:42932)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crebbp Mutation:  60 strains or lines available
References
Original:  J:42932 Tanaka Y, et al., Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10215-20
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory