Nkx3-1^tm1Hha
Targeted Allele Detail

Summary

• Symbol: Nkx3-1^tm1Hha
• Name: NK3 homeobox 1; targeted mutation 1, Hans-Henning Arnold
• MGI ID: MGI:1928654
• Synonyms: Nkx3.1 -
• Gene: Nkx3-1 Location: Chr14:69428141-69432107 bp, + strand Genetic Position: Chr14, 36.02 cM
• Alliance: Nkx3-1^tm1Hha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63764
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-PGK-neomycin resistance cassette replaced most of exon 2, which encodes the entire homeobox domain. (J:63764)

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-1 Mutation: 39 strains or lines available

References

• Original: J:63764 Schneider A, et al., Targeted disruption of the nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech Dev. 2000 Jul;95(1-2):163-74
• All: 2 reference(s)