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Grin2atm1Nak
Targeted Allele Detail
Nomenclature
Symbol: Grin2atm1Nak
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Shigetada Nakanishi
MGI ID: MGI:1928506
Synonyms: NR2A -, NR2A KO
Gene: Grin2a  Location: Chr16:9567898-9995560 bp, - strand  Genetic Position: Chr16, 5.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66455
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe region spanning the second transmembrane domain was deleted and replaced with a neomycin cassette. (J:66455)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Grin2a Mutation:  46 strains or lines available
References
Original:  J:66455 Kadotani H, et al., Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996 Dec 15;16(24):7859-67
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory