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Emx1tm1(cre)Ito
Targeted Allele Detail
Nomenclature
Symbol: Emx1tm1(cre)Ito
Name: empty spiracles homeobox 1; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:1928281
Synonyms: Emx1Cre, (Emx1)Cre, Emx1Cre, Emx1-Cre, Emx1tm1(cre)Rik
Gene: Emx1  Location: Chr6:85187931-85204463 bp, + strand  Genetic Position: Chr6, 37.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64064
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cDNA encoding cre recombinase with an N-terminal nuclear localization signal (nls) was inserted immediately before the translation initiation codon in the gene. Under the control of this promoter, Cre activity is detected by embryonic day 12.5; Cre mediated recombination was observed in dorsal telencephalon, neocortex, hippocampus, and olfactory bulb. An Frt flanked Neo cassette was retained in this allele (J:64064)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Emx1     Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:  27 strains or lines available
References
Original:  J:64064 Iwasato T, et al., Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature. 2000 Aug 17;406(6797):726-31
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory