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Grin1tm1Bhk
Targeted Allele Detail
Nomenclature
Symbol: Grin1tm1Bhk
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Beverly H Koller
MGI ID: MGI:1928280
Synonyms: GluN1Rneo, NR1-, NR1KD, Nr1neo, Nr1neo-
Gene: Grin1  Location: Chr2:25291181-25319187 bp, - strand  Genetic Position: Chr2, 17.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57125
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsHypomorphic allele. Insertion of a neomycin cassette into intron 20 of the gene reduces expression to ~5-10% of normal levels. (J:57125)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:  41 strains or lines available
References
Original:  J:57125 Mohn AR, et al., Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999 Aug 20;98(4):427-36
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory