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Targeted Allele Detail
Symbol: Casp1tm1Sesh
Name: caspase 1; targeted mutation 1, Tara Seshadri
MGI ID: MGI:1927822
Synonyms: casp-1-, Casp1 -, Casp1-/Casp11129mt, Caspase-1-, ICE -
Gene: Casp1  Location: Chr9:5298517-5307265 bp, + strand  Genetic Position: Chr9, 2.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:22964
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin expression cassette was inserted into exon 6, deleting 31 bp of sequence encoding the region of the active site and rendering the sequence out of frame after the insertion. Northern blot analysis on spleen RNA demonstrated an absence of the normal transcript in homozygous mice, and western blot analysis showed that the protein was not expressed in peritoneal macrophages of homozygous mice. This allele was generated in ES cells that lack protein expression of Casp11 (Casp129mt). (J:22964)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Casp1 Mutation:  5 strains or lines available
The ES cells used to generate this allele contain the linked Casp4del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Caspdel allele. J:193522

Original:  J:22964 Li P, et al., Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell. 1995 Feb 10;80(3):401-11
All:  84 reference(s)

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