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Cd74tm1Liz
Targeted Allele Detail
Nomenclature
Symbol: Cd74tm1Liz
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Elizabeth Bikoff
MGI ID: MGI:1927530
Synonyms: Ii-, Iitm1Liz, MHCII-
Gene: Cd74  Location: Chr18:60803848-60812646 bp, + strand  Genetic Position: Chr18, 34.41 cM
Sppl2atm1Basc/Sppl2atm1Basc Cd74tm1Liz/Cd74tm1Liz B cells show normal morphology compared to the increased vacuoles in Sppl2atm1Basc/Sppl2atm1Basc B cells

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65918
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A MC1neopA cassette replaced the first intron and 11 nucleotides of the second exon. (J:65918)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cd74 Mutation:  18 strains or lines available
References
Original:  J:65918 Bikoff EK, et al., Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J Exp Med. 1993 Jun 1;177(6):1699-712
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory