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H2-Ab1tm1Doi
Targeted Allele Detail
Nomenclature
Symbol: H2-Ab1tm1Doi
Name: histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID: MGI:1927483
Synonyms: AB0, Abbeta-, Abeta-, A beta0, Class II0, H2-Ab1tm1Dim, H2-Ab1tm1Doi, II0, MHC class II-, MHCII-, MHC-II-k.o.
Gene: H2-Ab1  Location: Chr17:34263227-34269418 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65736
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe second exon was disrupted by the insertion of a neomycin resistance gene. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. (J:65736)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 24 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:  66 strains or lines available
References
Original:  J:65736 Cosgrove D, et al., Mice lacking MHC class II molecules. Cell. 1991 Sep 6;66(5):1051-66
All:  153 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory