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Targeted Allele Detail
Symbol: Nkx2-5tm1Wehi
Name: NK2 homeobox 5; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
MGI ID: MGI:1927227
Synonyms: Nkx2-5HDneo
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:27443
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA replacement-type targeting vector was constructed in which sequences coding for helix 3 of the homeodomain were disrupted by insertion of a neoR gene cassette. (J:27443)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 33 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
Original:  J:27443 Lyons I, et al., Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995 Jul 1;9(13):1654-66
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory