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B2mtm1Jae
Targeted Allele Detail
Nomenclature
Symbol: B2mtm1Jae
Name: beta-2 microglobulin; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1927183
Synonyms: B2M-, beta2M-, beta2mnull, MHC classI-
Gene: B2m  Location: Chr2:122147686-122153083 bp, + strand  Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65613
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into the second exon. (J:65613, J:80910)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any B2m Mutation:  46 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hemochromatosis in homozygous mice (J:17527)

References
Original:  J:65613 Zijlstra M, et al., Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature. 1989 Nov 23;342(6248):435-8
All:  182 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory