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Nf2tm2Gth
Targeted Allele Detail
Nomenclature
Symbol: Nf2tm2Gth
Name: neurofibromatosis 2; targeted mutation 2, Gilles Thomas
MGI ID: MGI:1926955
Synonyms: Nf2F, Nf2flox2, Nf2lox
Gene: Nf2  Location: Chr11:4765845-4849536 bp, - strand  Genetic Position: Chr11, 3.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63264
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Insertion of loxP sites flanking exon 2 of the Nf2 gene. No effect on the function of Nf2. (J:63264)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nf2 Mutation:  47 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Renal Cell Carcinoma (Nf2tm2Gth Tg(Vil-cre)20Syr; J:150071)

References
Original:  J:63264 Giovannini M, et al., Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory