Nf2^tm2Gth
Targeted Allele Detail

Summary

• Symbol: Nf2^tm2Gth
• Name: neurofibromin 2; targeted mutation 2, Gilles Thomas
• MGI ID: MGI:1926955
• Synonyms: Nf2^F, Nf2^flox2, Nf2^lox
• Gene: Nf2 Location: Chr11:4715845-4799536 bp, - strand Genetic Position: Chr11, 3.0 cM
• Alliance: Nf2^tm2Gth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63264
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Insertion of loxP sites flanking exon 2 of the Nf2 gene. No effect on the function of Nf2. (J:63264)

Disease models

Expression

In Mice Carrying this Mutation:	165 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nf2^tm2Gth

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nf2 Mutation: 65 strains or lines available

References

• Original: J:63264 Giovannini M, et al., Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 2000 Jul 1;14(13):1617-30
• All: 53 reference(s)