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Targeted Allele Detail
Symbol: Pax5tm1Mbu
Name: paired box 5; targeted mutation 1, Meinrad Busslinger
MGI ID: MGI:1926938
Synonyms: Pax5-, Pax5lacZ, Pax5-lacZ
Gene: Pax5  Location: Chr4:44524757-44710487 bp, - strand  Genetic Position: Chr4, 23.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:21935
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsDisruption of the Pax5 gene by an in-frame fusion of the 5'genomic sequences of Pax5 (at codon 21 in exon 2) to a LacZ reporter gene containing a nuclear localization signal. (J:21935)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax5 Mutation:  19 strains or lines available
Original:  J:21935 Urbanek P, et al., Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP [see comments]. Cell. 1994 Dec 2;79(5):901-12
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory