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Targeted Allele Detail
Symbol: Cdkn2atm1Cjs
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Charles J Scherr
MGI ID: MGI:1926877
Synonyms: ARF-, p19Arf-, p19ARF-, p19Arf-null
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Abnormal retrolental tissue present in the eyes of neonatal Cdkn2atm1Cjs/Cdkn2atm1Cjs mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:44427
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of exon 1 beta of the Cdkn2a gene, encoding the translation start site for alternative splice transcript p19ARF, with a neomycin cassette. Note that expression of alternative splice transcript p16Ink4a, transcribed from exon 1 alpha, is not affected by this mutation. (J:44427)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  57 strains or lines available
Phenotypic Similarity to Human Syndrome: Rhabdomyosarcoma, Embryonal J: 237183 in mice homozygous for Cdkn2atm1Cjs and hemizygous for Tg(CKMM-tTA)A3Rhvh and Tg(tetO-Hgf,-EGFP)24Tcre.
Original:  J:44427 Kamijo T, et al., Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997 Nov 28;91(5):649-59
All:  155 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory