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Targeted Allele Detail
Symbol: Phox2btm1Jbr
Name: paired-like homeobox 2b; targeted mutation 1, Jean-Francois Brunet
MGI ID: MGI:1926861
Synonyms: Phox2b-, Phox2bLacZ
Gene: Phox2b  Location: Chr5:67094399-67099301 bp, - strand  Genetic Position: Chr5, 35.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:55391
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsInsertion of a lacZ gene in frame into the second exon, which encodes the homeobox domain. A neomycin resistance cassette follows the lacZ gene. This allele expresses beta-galctosidase under the control of the endogenous promoter elements. (J:55391)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 104 assay results
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2b Mutation:  10 strains or lines available
Original:  J:55391 Pattyn A, et al., The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 1999 May 27;399(6734):366-70
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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