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Chek1tm1Sje
Targeted Allele Detail
Nomenclature
Symbol: Chek1tm1Sje
Name: checkpoint kinase 1; targeted mutation 1, Stephen J Elledge
MGI ID: MGI:1926528
Synonyms: CHK1-
Gene: Chek1  Location: Chr9:36708482-36727065 bp, - strand  Genetic Position: Chr9, 20.67 cM, cytoband A5.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62919
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of 3kb of the gene encoding the translation start site, the "GxGxxG" ATP-binding motif and half of the kinase domain with a neomycin gene. (J:62919)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chek1 Mutation:  28 strains or lines available
References
Original:  J:62919 Liu Q, et al., Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000 Jun 15;14(12):1448-59
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory