Igf1^tm1Arge
Targeted Allele Detail

Summary

• Symbol: Igf1^tm1Arge
• Name: insulin-like growth factor 1; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:1926485
• Synonyms: I-, Igf1-, Igf-I-
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^tm1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15108
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of sequences encoding part of exon 4 with a neomycin resistance gene. (J:15108)

Expression

In Mice Carrying this Mutation:	143 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 27 strains or lines available

References

• Original: J:15108 Liu JP, et al., Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993 Oct 8;75(1):59-72
• All: 45 reference(s)