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Msx2tm1Rilm
Targeted Allele Detail
Summary
Symbol: Msx2tm1Rilm
Name: msh homeobox 2; targeted mutation 1, Richard Maas
MGI ID: MGI:1926381
Synonyms: Msx2-
Gene: Msx2  Location: Chr13:53620917-53626816 bp, - strand  Genetic Position: Chr13, 27.84 cM
Alliance: Msx2tm1Rilm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61509
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsGene disruption caused by insertion of a pMC1-neo cassette into coding sequences located just 5' to the homeobox domain in exon 2. (J:61509)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 106 assay results
In Structures Affected by this Mutation: 39 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Msx2 Mutation:  23 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Peters anomaly in homozygous mice (J:184697)
References
Original:  J:61509 Satokata I, et al., Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet. 2000 Apr;24(4):391-5
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory