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Tsc2tm1Tno
Targeted Allele Detail
Nomenclature
Symbol: Tsc2tm1Tno
Name: TSC complex subunit 2; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:1926345
Synonyms: Tsc2-
Gene: Tsc2  Location: Chr17:24595816-24632630 bp, - strand  Genetic Position: Chr17, 12.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52464
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3kb genomic fragment that contains part of exon 2, all of exons 3 and 4, and part of exon 5 was replaced by a promoterless NLS-lacZ gene fused in-frame to exon 2, followed by a floxed PGK-neomycin resistance cassette. (J:52464)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:  43 strains or lines available
References
Original:  J:52464 Kobayashi T, et al., Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res. 1999 Mar 15;59(6):1206-11
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory