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Targeted Allele Detail
Symbol: Tcf7l2tm1Cle
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 1, Hans Clevers
MGI ID: MGI:1926344
Synonyms: Tcf-4-, Tcf4-, Tcf7l2-
Gene: Tcf7l2  Location: Chr19:55741820-55933654 bp, + strand  Genetic Position: Chr19, 51.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:48968
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsGene disruption caused by insertion of a PGK-hygromycin selection cassette into the exon containing coding sequences for the N-terminal region of the DNA-binding HMG box. (J:48968)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  35 strains or lines available
Original:  J:48968 Korinek V, et al., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet. 1998 Aug;19(4):379-83
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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