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Atmtm1Bal
Targeted Allele Detail
Nomenclature
Symbol: Atmtm1Bal
Name: ataxia telangiectasia mutated; targeted mutation 1, David Baltimore
MGI ID: MGI:1926343
Synonyms: ATM-
Gene: Atm  Location: Chr9:53439149-53536740 bp, - strand  Genetic Position: Chr9, 29.12 cM, cytoband C-D
Electron micrographs of wild type and Atmtm1Bal/Atmtm1Bal Purkinje neurons

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42324
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of an exon encoding the kinase-conserved sequence of Atm and the following 3' exon was replaced with a PGK-neomycin cassette. (J:42324)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atm Mutation:  32 strains or lines available
References
Original:  J:42324 Xu Y, et al., Dual roles of ATM in the cellular response to radiation and in cell growth control [see comments]. Genes Dev. 1996 Oct 1;10(19):2401-10
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory