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Targeted Allele Detail
Symbol: Myf6tm1Eno
Name: myogenic factor 6; targeted mutation 1, Eric N Olson
MGI ID: MGI:1913092
Synonyms: Mrf4-
Gene: Myf6  Location: Chr10:107492860-107494729 bp, - strand  Genetic Position: Chr10, 55.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:26105
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette was inserted into the Myf6 gene such that all sequences 3' of codon 69 are removed. These deleted sequences encode the bHLH region of the 1st exon and the entire carboxyl terminus. Myf5 expression does not appear to be altered in this allele. (J:26105)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myf6 Mutation:  8 strains or lines available
Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression. This allele (Myf6tm1Eno) does not display reduced expression of Myf5 and thus may exhibit the true Myf6 null phenotype unlike other Myf6 alleles that may have phenotypes resulting from the reduction or lack of Myf5 (J:26105, J:42453).
Original:  J:26105 Zhang W, et al., Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99
All:  10 reference(s)

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MGI 6.06
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