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Chemically induced Allele Detail
Symbol: Myo6Mhdatlc
Name: myosin VI; Martin Hrabe de Angelis tailchaser
MGI ID: MGI:1913078
Synonyms: ABE1, Myo6Tlc, tailchaser, Tlc
Gene: Myo6  Location: Chr9:80165031-80311729 bp, + strand  Genetic Position: Chr9, 43.98 cM
Strain of Origin:  C3HeB/FeJ
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsSequencing of cDNA extracted and amplified from heterozygous brains revealed a c.G694T transversion in a region that corresponds to exon 6 of the gene. This mutation is predicted to result in an aspartic acid to tyrosine amino acid substitution at the highly conserved position 179 of the encoded protein. (J:161272)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myo6 Mutation:  46 strains or lines available
Original:  J:64900 Kiernan AE, et al., Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival. J Neurocytol. 1999 Oct-Nov;28(10-11):969-85
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory