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Transgenic Allele Detail
Symbol: Klkl
Name: klotho
MGI ID: MGI:1889570
Synonyms: alpha-kl-, kl, Kl-, klothohm
Gene: Kl  Location: Chr5:150952607-150993817 bp, + strand  Genetic Position: Chr5, 89.77 cM, cytoband G3
Strain of Origin:  C57BL/6J and C3H/HeJ
Transgene Type:    Transgenic
Mutation:    Deletion
Mutation detailsThis allele was discovered after mating and screening mice that did not express an exogenous transgene (rabbit type-I sodium-proton exchanger) in other work. One offspring from these matings showed an interesting phenotype, and the mutant was named klotho. It was determined that insertion of the unrelated, exogenous transgene had caused an 8 kb deletion in the 5' upstream region of the Kl locus in the mutant animal. (J:44109)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kl Mutation:  6 strains or lines available
Original:  J:44109 Kuro-o M, et al., Mutation of the mouse klotho gene leads to a syndrome resembling ageing [see comments]. Nature. 1997 Nov 6;390(6655):45-51
All:  76 reference(s)

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MGI 6.01
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