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Allele Detail
Symbol: Bey
Name: bulgy-eye
MGI ID: MGI:1889298
Gene: Bey  Location: unknown  Genetic Position: Chr7, Syntenic
Strain of Origin:  129S/SvEv-Oca2+ Tyr+
Allele Type:    Not Applicable
Mutation:    Insertion
Mutation detailsThis mutation was induced by retroviral mutagenesis using an 8.0 kb myeloproliferative sarcoma retrovirus MPSV-mos-neo in mouse embryonic stem cells; an additional 154 bp of unique sequence also integrated at the locus during mutagenesis. The insertion site was identified as the intergenic region between Fgf3 and Fgf4. The retrovirus landed in the opposite transcriptional orientation to both genes and is approximately 10 kb downstream of Fgf3 and 5 kb upstream of Fgf4. Ectopic expression of both genes was up-regulated in the cranial suture region in mutant mice. (J:47965)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bey Mutation:  0 strains or lines available
Original:  J:47965 Carlton MB, et al., Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus. Dev Dyn. 1998 Jun;212(2):242-9
All:  1 reference(s)

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