About   Help   FAQ
Targeted Allele Detail
Symbol: Camk4tm1Tch
Name: calcium/calmodulin-dependent protein kinase IV; targeted mutation 1, Talal A Chatila
MGI ID: MGI:1888972
Synonyms: Camk4-, CaMKIV/Gr KO
Gene: Camk4  Location: Chr18:32934931-33191228 bp, + strand  Genetic Position: Chr18, 18.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:64210
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe replacement of the third exon, which encodes the ATP binding site in the catalytic domain of the kinase, with a neomycin resistance gene rendered the enzyme catalytically inactive and prone to degradation. (J:64210)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camk4 Mutation:  3 strains or lines available
Original:  J:64210 Ho N, et al., Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000 Sep 1;20(17):6459-72
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory