E2f4^tm1Jrn
Targeted Allele Detail

Summary

• Symbol: E2f4^tm1Jrn
• Name: E2F transcription factor 4; targeted mutation 1, Joseph R Nevins
• MGI ID: MGI:1888951
• Synonyms: E2F4^-
• Gene: E2f4 Location: Chr8:106024295-106032002 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: E2f4^tm1Jrn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64192
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The null allele was generated by replacing the first three exons of the wild-type locus with a PGK-neo cassette. (J:64192)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f4 Mutation: 21 strains or lines available

References

• Original: J:64192 Rempel RE, et al., Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell. 2000 Aug;6(2):293-306
• All: 8 reference(s)