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Stat6tm1Gru
Targeted Allele Detail
Nomenclature
Symbol: Stat6tm1Gru
Name: signal transducer and activator of transcription 6; targeted mutation 1, Michael J Grusby
MGI ID: MGI:1888385
Synonyms: S6KO, Stat6-
Gene: Stat6  Location: Chr10:127478855-127496826 bp, + strand  Genetic Position: Chr10, 74.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31932
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe region encoding the SH2 domain, which is essential for dimerization, was replaced by the insertion of a neomycin selection cassette. Immunoblot analysis of lysates from the spleens and thymi of homozygous mutant mice showed an absence of encoded protein. (J:31932)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Stat6 Mutation:  37 strains or lines available
References
Original:  J:31932 Kaplan MH, et al., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar;4(3):313-9
All:  342 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory