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Targeted Allele Detail
Symbol: Scarb1tm1Kri
Name: scavenger receptor class B, member 1; targeted mutation 1, Monty Krieger
MGI ID: MGI:1888384
Synonyms: srb1-, Sr-b1-, srbI-, SR-BI, SR-BI-, SR-BI KO
Gene: Scarb1  Location: Chr5:125277087-125341094 bp, - strand  Genetic Position: Chr5, 64.11 cM
Apoetm1Unc/Apoetm1Unc Scarb1tm1Kri/Scarb1tm1Kri mice develop occlusive, atherosclerotic coronary artery disease

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:44187
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette. (J:44187)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scarb1 Mutation:  9 strains or lines available
Phenotypic Similarity to Human Syndrome: Coronary Artery Disease (CAD) in mice homozygous for Apoe tm1Unc and Scarb1 tm1Kri on a mixed 129, BALB/c and C57BL/6 background (J:201999)

Original:  J:44187 Rigotti A, et al., A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12610-5
All:  93 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory