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Targeted Allele Detail
Symbol: Sparctm1Hwe
Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe
MGI ID: MGI:1888383
Synonyms: SP-
Gene: Sparc  Location: Chr11:55284985-55310906 bp, - strand  Genetic Position: Chr11, 33.04 cM, cytoband B1
Delayed wound healing in Sparctm1Hwe/Sparctm1Hwe mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:52120
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsTwo tandem neomycin resistance cassettes were inserted into exon 4. No mRNA was detected by Northern blot in testis, spleen or thymus of homozygous mice. (J:52120)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Sparc Mutation:  80 strains or lines available
Original:  J:52120 Norose K, et al., SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2674-80
All:  88 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory