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Sparctm1Hwe
Targeted Allele Detail
Nomenclature
Symbol: Sparctm1Hwe
Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe
MGI ID: MGI:1888383
Synonyms: SP-
Gene: Sparc  Location: Chr11:55394500-55420080 bp, - strand  Genetic Position: Chr11, 33.04 cM, cytoband B1
Delayed wound healing in Sparctm1Hwe/Sparctm1Hwe mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52120
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsTwo tandem neomycin resistance cassettes were inserted into exon 4. No mRNA was detected by Northern blot in testis, spleen or thymus of homozygous mice. (J:52120)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sparc Mutation:  76 strains or lines available
References
Original:  J:52120 Norose K, et al., SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2674-80
All:  70 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory