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Prlrtm1Cnp
Targeted Allele Detail
Nomenclature
Symbol: Prlrtm1Cnp
Name: prolactin receptor; targeted mutation 1, Paul A Kelly
MGI ID: MGI:1888377
Synonyms: Prlr-, PRLRko
Gene: Prlr  Location: Chr15:10177238-10349180 bp, + strand  Genetic Position: Chr15, 5.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38093
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into exon 5, creating an in-frame stop codon. Northern, Western, and binding data all demonstrate the lack of a functional receptor in homozygous mutant animals. (J:38093)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Prlr Mutation:  4 strains or lines available
References
Original:  J:38093 Ormandy CJ, et al., Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997 Jan 15;11(2):167-78
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory