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Targeted Allele Detail
Symbol: Ntrk3tm1Bbd
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1888375
Synonyms: trkC-, trkCK-, trkCTK
Gene: Ntrk3  Location: Chr7:78179986-78581034 bp, - strand  Genetic Position: Chr7, 44.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:17195
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette into exon K2, which encodes part of the kinase domain of the protein. An alternatively spliced mRNA was detectable in an RNase protection analysis on tissues derived from homozygous mutant mice; these transcripts spliced from exon K1 to K3. A partial protein product is predicted to be expressed from this allele. (J:17195)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:  9 strains or lines available
Original:  J:17195 Klein R, et al., Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements [see comments]. Nature. 1994 Mar 17;368(6468):249-51
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory