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Ntrk3tm1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Ntrk3tm1Bbd
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1888375
Synonyms: trkC-, trkCK-, trkCTK
Gene: Ntrk3  Location: Chr7:78175959-78738012 bp, - strand  Genetic Position: Chr7, 44.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17195
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette into exon K2, which encodes part of the kinase domain of the protein. An alternatively spliced mRNA was detectable in an RNase protection analysis on tissues derived from homozygous mutant mice; these transcripts spliced from exon K1 to K3. A partial protein product is predicted to be expressed from this allele. (J:17195)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:  35 strains or lines available
References
Original:  J:17195 Klein R, et al., Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements [see comments]. Nature. 1994 Mar 17;368(6468):249-51
All:  38 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory