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Ntrk1tm1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Ntrk1tm1Bbd
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1888374
Synonyms: trkA-, trkAK-, trkTK
Gene: Ntrk1  Location: Chr3:87778244-87795162 bp, - strand  Genetic Position: Chr3, 38.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17194
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. (J:17194)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  34 strains or lines available
References
Original:  J:17194 Smeyne RJ, et al., Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene [see comments]. Nature. 1994 Mar 17;368(6468):246-9
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory