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Aff1Rob
Chemically induced Allele Detail
Nomenclature
Symbol: Aff1Rob
Name: AF4/FMR2 family, member 1; robotic
MGI ID: MGI:1862020
Synonyms: Gena180, GENA 180, Rob
Gene: Aff1  Location: Chr5:103692374-103855322 bp, + strand  Genetic Position: Chr5, 50.45 cM, cytoband E
Mutation
origin
Strain of Origin:  BALB/cAnNCrl
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThe mutation in the robotic mouse was identified as a T to C transition in the second base of codon 280 resulting in a valine to alanine substitution (p.V280A) in a highly conserved region of the encoded protein. (J:82265)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Aff1 Mutation:  272 strains or lines available
References
Original:  J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory