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Targeted Allele Detail
Symbol: Map2k4tm1Lizon
Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Leonard I Zon
MGI ID: MGI:1861969
Synonyms: SEK1-
Gene: Map2k4  Location: Chr11:65688243-65788297 bp, - strand  Genetic Position: Chr11, 40.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:48772
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette disrupted two exons encoding part of the catalytic domain of the protein. Western blots of embryonic fibroblasts from homozygous mutant mice showed no detectable protein for the targeted gene. (J:48772)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:  7 strains or lines available
Original:  J:48772 Ganiatsas S, et al., SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6881-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory