About   Help   FAQ
Stat1tm1Rds
Targeted Allele Detail
Nomenclature
Symbol: Stat1tm1Rds
Name: signal transducer and activator of transcription 1; targeted mutation 1, Robert D Schreiber
MGI ID: MGI:1861949
Synonyms: 129:Stat1-null, S1KO, STAT1-
Gene: Stat1  Location: Chr1:52119440-52161865 bp, + strand  Genetic Position: Chr1, 26.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31326
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first three coding exons and 0.7kb of 5' upstream flanking sequence. (J:31326)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  24 strains or lines available
References
Original:  J:31326 Meraz MA, et al., Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996 Feb 9;84(3):431-42
All:  197 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/12/2019
MGI 6.14
The Jackson Laboratory