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Stat1tm1Rds
Targeted Allele Detail
Summary
Symbol: Stat1tm1Rds
Name: signal transducer and activator of transcription 1; targeted mutation 1, Robert D Schreiber
MGI ID: MGI:1861949
Synonyms: 129:Stat1-null, S1KO, STAT1-
Gene: Stat1  Location: Chr1:52158599-52201024 bp, + strand  Genetic Position: Chr1, 26.81 cM
Alliance: Stat1tm1Rds page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31326
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first three coding exons and 0.7kb of 5' upstream flanking sequence. (J:31326)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Stat1tm1Rds
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  72 strains or lines available
References
Original:  J:31326 Meraz MA, et al., Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996 Feb 9;84(3):431-42
All:  233 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory