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H2-DMatm1Luc
Targeted Allele Detail
Nomenclature
Symbol: H2-DMatm1Luc
Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Luc van Kaer
MGI ID: MGI:1861933
Synonyms: H2-DM-, H-2M-, H2-M-, H2-M0, H2-Malpha-
Gene: H2-DMa  Location: Chr17:34338667-34358075 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31625
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.5 kb fragment of the gene, encompassing the first and most of the second exon. (J:31625)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-DMa Mutation:  19 strains or lines available
References
Original:  J:31625 Martin WD, et al., H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 1996 Feb 23;84(4):543-50
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory