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Targeted Allele Detail
Symbol: Eportm1Lizon
Name: erythropoietin receptor; targeted mutation 1, Leonard I Zon
MGI ID: MGI:1861922
Synonyms: EpoR-
Gene: Epor  Location: Chr9:21958897-21963506 bp, - strand  Genetic Position: Chr9, 7.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:35594
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing the splice acceptor site of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. RT-PCR analysis on E12 peripheral blood of homozygous E12 embryos demonstrated that no detectable transcript was produced from this allele. (J:35594)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  12 strains or lines available
Original:  J:35594 Kieran MW, et al., Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9126-31
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory