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Targeted Allele Detail
Symbol: Epas1tm1Rus
Name: endothelial PAS domain protein 1; targeted mutation 1, David W Russell
MGI ID: MGI:1861921
Synonyms: Epas1-, HIF2alphaLacZ
Gene: Epas1  Location: Chr17:86753864-86833410 bp, + strand  Genetic Position: Chr17, 56.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:50964
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ gene was inserted and fused in-frame into exon 2, and was followed by a neomycin selection cassette. Western blot analysis indicated that the expression of wild-type transcript was eliminated from this allele. However, a beta-galactosidase fusion protein was expressed under the control of the endogenous promoter. (J:50964)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  46 strains or lines available
Original:  J:50964 Tian H, et al., The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998 Nov 1;12(21):3320-4
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory