About   Help   FAQ
Targeted Allele Detail
Symbol: Cyp1a2tm1Gonz
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:1861917
Synonyms: Cyp1a2-, CYP1A2-
Gene: Cyp1a2  Location: Chr9:57676937-57683655 bp, - strand  Genetic Position: Chr9, 31.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:25724
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into exon 2, which is the first coding exon. Western blot analysis on liver microsomes derived from adult homozygous mice demonstrated that no detectable protein was encoded by this allele. (J:25724)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp1a2 Mutation:  20 strains or lines available
Original:  J:25724 Pineau T, et al., Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc Natl Acad Sci U S A. 1995 May 23;92(11):5134-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory