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Cyp1a2tm1Gonz
Targeted Allele Detail
Nomenclature
Symbol: Cyp1a2tm1Gonz
Name: cytochrome P450, family 1, subfamily a, polypeptide 2; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:1861917
Synonyms: Cyp1a2-, CYP1A2-
Gene: Cyp1a2  Location: Chr9:57676937-57683655 bp, - strand  Genetic Position: Chr9, 31.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:25724
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into exon 2, which is the first coding exon. Western blot analysis on liver microsomes derived from adult homozygous mice demonstrated that no detectable protein was encoded by this allele. (J:25724)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp1a2 Mutation:  11 strains or lines available
References
Original:  J:25724 Pineau T, et al., Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc Natl Acad Sci U S A. 1995 May 23;92(11):5134-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory