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Targeted Allele Detail
Symbol: Cdh6tm1Sma
Name: cadherin 6; targeted mutation 1, Steven P Mah
MGI ID: MGI:1861807
Synonyms: Cad-6 -
Gene: Cdh6  Location: Chr15:13028701-13173675 bp, - strand  Genetic Position: Chr15, 6.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:63195
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted into exon 1 at codon 68. Western blot analysis on embryonic kidney lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. Immunohistochemistry expermients confirmed that homozygous mice did not express detectable levels of the encoded protein (data not shown). (J:63195)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh6 Mutation:  25 strains or lines available
Original:  J:63195 Mah SP, et al., Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons. Dev Biol. 2000 Jul 1;223(1):38-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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