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Cd80tm1Shr
Targeted Allele Detail
Nomenclature
Symbol: Cd80tm1Shr
Name: CD80 antigen; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:1861804
Synonyms: B7-, B7-1-, B7.1, CD80-
Gene: Cd80  Location: Chr16:38458933-38486933 bp, + strand  Genetic Position: Chr16, 26.86 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74662
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. (J:74662)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd80 Mutation:  38 strains or lines available
References
Original:  J:74662 Freeman GJ, et al., Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science. 1993 Nov 5;262(5135):907-9
All:  133 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory