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Targeted Allele Detail
Symbol: Cd80tm1Shr
Name: CD80 antigen; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:1861804
Synonyms: B7-, B7-1-, B7.1, CD80-
Gene: Cd80  Location: Chr16:38457430-38495958 bp, + strand  Genetic Position: Chr16, 26.86 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:74662
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. (J:74662)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd80 Mutation:  40 strains or lines available
Original:  J:74662 Freeman GJ, et al., Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science. 1993 Nov 5;262(5135):907-9
All:  143 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory