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Targeted Allele Detail
Symbol: Cd80tm1Shr
Name: CD80 antigen; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:1861804
Synonyms: B7-, B7-1-, B7.1, CD80-
Gene: Cd80  Location: Chr16:38458933-38486933 bp, + strand  Genetic Position: Chr16, 26.86 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:74662
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the exon encoding the IgV-like domain of the protein. RT-PCR analysis on RNA derived from spleen, thymus and LPS-stimulated B cells of homozygous mice demonstrated that no detectable transcript was produced from this allele. FACS analysis on B cells derived from homozygous mice confirmed that no functional protein was encoded by this allele. (J:74662)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd80 Mutation:  38 strains or lines available
Original:  J:74662 Freeman GJ, et al., Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science. 1993 Nov 5;262(5135):907-9
All:  132 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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